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Cryo-EM wins over NMR and crystallography

Structure of human γ-secretase is finally obtained! Group leaded by Sjors Scheres from LMB in Cambridge used cryo-EM technique to reveal it at resolution of 4.5 Å! They published their findings in Nature.  The discovery is of great importance as mutations in human γ-secretase have been shown to play crucial role in Alzheimer’s disease. Mutated enzyme hydrolyzes amyloid precursor … Continue reading